Finding DRUG for swine flu.

Many infectious diseases have been eliminated over the past century,but microorganism still pose a significant and increasing threat.the recent emergence (april-2009) of the new pandemic strain H1N1-SWINE FLU virus poses a challenge to the existing medical capabilities.the aim of the researchers is to find out the most effective drug among the existing ones for influenza virus.the current drug targets neuraminidase and lon-channel proteins (M2-protein) of H1N1 VIRUS proteins plays a major role in the effective replication and release of virion in spreading the disease.zanåmivir and oseltamivir are the neuraminidase-inhibitors.amantadine and rimatidine acts towards lon-channel protein(M2-protein) .among the 11 proteins of swine virus only two has been targeted towards drug designing.the protein PB1 and NS1(non structural) plays significant roles in the virulence and suppression of interferon response in the virus infected cells.the structure of proteins PB1 and NS1 were modeled using SWISS MODEL.it has been structurally and functionally determined in protein databases.the lead molecules binding to these targets were identified using structure based drug designing.